Immune Response Of Chicks To Inactivated Avian Influenza Virus H9N2 Vaccine And Vitamin E Supplementation
By: Zahid Munir
| Dr.Masood Rabbani.
Contributor(s): Dr.Khalid Saeed | Miss Sameera Akhtar | Faculty of Veterinary Sciences.
Material type: 
BookPublisher: 2001Subject(s): Department of MicrobiologyDDC classification: 0716,T Dissertation note: The present study was undertaken with the objectives to isolate and characterize avian influenza virus (A IV) involved in high morbidity and mortality in chicken flocks in Karachi area. AIV H9N2 type was isolated from the morbid tissue sample. Inactivated alum precipitated and oil adjuvanted vaccines were prepared from local isolate and inoculated to two groups of chicken. One of AIV-H9N2 vaccine inoculated group was also supplemented with vitamin in feed.
This study indicates that AIV-H9N2 was immunogenic and the experimental chicks were immunocompetent as the vaccinated chicks indicated humoral antibodies in their sera. On day 49 the AIV-HI titer range recorded in the serum samples of chicks from group Ai were 64- 256, and titers in sera from group A2 were 64-256. The supplementation of vitamin-E indicated vitamin-E as an anti-stress agent and improved weight gains and FCR in the chicks of group A2. The mean body weights of chicks in group B (control), Ai (vaccinated untreated) and A2 (vaccinated and vitamin-E supplemented) at 63rd day of age were 1750,1750 and 1850 grams respectively. Statistical analysis of the mean thymus body weight, bursal body weight and spleenic body weight indices from treatment groups Ai and A2 and those untreated control B group were significantly different from each other using LSD test (p>0.05).
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Thesis
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UVAS Library Thesis Section | Veterinary Science | 0716,T (Browse shelf) | Available | 0716,T |
The present study was undertaken with the objectives to isolate and characterize avian influenza virus (A IV) involved in high morbidity and mortality in chicken flocks in Karachi area. AIV H9N2 type was isolated from the morbid tissue sample. Inactivated alum precipitated and oil adjuvanted vaccines were prepared from local isolate and inoculated to two groups of chicken. One of AIV-H9N2 vaccine inoculated group was also supplemented with vitamin in feed.
This study indicates that AIV-H9N2 was immunogenic and the experimental chicks were immunocompetent as the vaccinated chicks indicated humoral antibodies in their sera. On day 49 the AIV-HI titer range recorded in the serum samples of chicks from group Ai were 64- 256, and titers in sera from group A2 were 64-256. The supplementation of vitamin-E indicated vitamin-E as an anti-stress agent and improved weight gains and FCR in the chicks of group A2. The mean body weights of chicks in group B (control), Ai (vaccinated untreated) and A2 (vaccinated and vitamin-E supplemented) at 63rd day of age were 1750,1750 and 1850 grams respectively. Statistical analysis of the mean thymus body weight, bursal body weight and spleenic body weight indices from treatment groups Ai and A2 and those untreated control B group were significantly different from each other using LSD test (p>0.05).
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